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Meike V. Beer, Claudia Rech, Peter Gasteier, Birgit Sauerzapfe, Jochen Salber, Andrea Ewald, Martin Möller, Lothar Elling and Jürgen Groll The Next Step in Biomimetic Material Design: Poly-LacNAc-Mediated Reversible Exposure of Extra Cellular Matrix Components Advanced Healthcare Materials 2

Version of Record online: 2 OCT 2012 | DOI: 10.1002/adhm.201200080

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Herein is demonstrated that a biomimetic, in-vivo-like presentation of extracellular matrix (ECM) proteins such as fibronectin, laminin, and collagen IV mediated by a fully functional poly-sugar (polyLacNAc)–lectin complex can be achieved on a biomaterials surface. Cells recognize and bind to these immobilized proteins and can, due to the reversible protein presentation, remodel initially presented ECM proteins.

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