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Lei Song, Vincent H.B. Ho, Chun Chen, Zhongqiang Yang, Dongsheng Liu, Rongjun Chen and Dejian Zhou Efficient, pH-Triggered Drug Delivery Using a pH-Responsive DNA-Conjugated Gold Nanoparticle Advanced Healthcare Materials 2

Version of Record online: 4 OCT 2012 | DOI: 10.1002/adhm.201200112

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A novel drug nanocarrier that offers simple, direct, native form drug loading without involving any chemical modification and/or coupling step has been developed by using a pH-responsive DNA–gold nanoparticle conjugate. It can resist non-specific adsorption of serum proteins upon PEGylation and can provide efficient delivery and pH-triggered release of anticancer drugs to cancer cells, leading to high cytotoxicity.

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