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Xing Ma, Kim Truc Nguyen, Parijat Borah, Chung Yen Ang and Yanli Zhao Functional Silica Nanoparticles for Redox-Triggered Drug/ssDNA Co-delivery Advanced Healthcare Materials 1

Article first published online: 25 JUL 2012 | DOI: 10.1002/adhm.201200123

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A mesoporous silica nanoparticle based co-delivery system is developed in order to deliver simultaneously drug and single strand DNA in a controlled manner. Ammonium units containing cleavable disulfide bonds are introduced onto the nanoparticle surface. Thus, negatively charged single strand DNA is immobilized onto the nanoparticle surface through electrostatic interactions with the ammonium units, effectively blocking the loaded drugs within the mesopores of the nanoparticles. The pre-installed disulfide bonds on the nanoparticle surface can be cleaved by the addition of the reducing agent, leading to the co-delivery of the single strand DNA and drugs. High co-delivery efficiency of the biocompatible nanoparticles is demonstrated in vitro, indicating the successful release of both anticancer drugs and single strand DNA into Hela cancer cells for improved apoptosis.

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