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Wuxiao Ding, Naohiro Kameta, Hiroyuki Minamikawa, Momoyo Wada, Toshimi Shimizu and Mitsutoshi Masuda Hybrid Organic Nanotubes with Dual Functionalities Localized on Cylindrical Nanochannels Control the Release of Doxorubicin Advanced Healthcare Materials 1

Article first published online: 30 AUG 2012 | DOI: 10.1002/adhm.201200133

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The construction, via a co-assembly approach, of hybrid organic nanotubes with dual functionalities (–COOH and benzyloxycarbonyl) localized on cylindrical nanochannels is demonstrated. The nanotubes effectively encapsulate doxorubicin (Dox) into their nanospace via complex formation between –COO groups and the –NH3+ of Dox, and sustained release of doxorubicin is achieved owing to hydrophobic interaction between benzyloxycarbonyl groups and the anthracycline moiety of doxorubicin.

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