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Swati Midha, Wouter van den Bergh, Taek B. Kim, Peter D. Lee, Julian R. Jones and Christopher A. Mitchell Bioactive Glass Foam Scaffolds are Remodelled by Osteoclasts and Support the Formation of Mineralized Matrix and Vascular Networks In Vitro Advanced Healthcare Materials 2

Version of Record online: 22 OCT 2012 | DOI: 10.1002/adhm.201200140

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70S30C sol–gel bioactive glasses induce murine MC3T3-E1 pre-osteogenic cells to proliferate in response to ionic dissolution products and promote surface remodelling by deposition of mineralized osteoid in vitro. C7 macrophages also differentiate into TRAP+ve osteoclasts forming distinctive resorption pits and endothelial cells form tube-like structures. Thus 70S30C foams are excellent candidates for vascularised bone regeneration studies.

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