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Haiyang Yu, Chor Yong Tay, Mintu Pal, Wen Shing Leong, Huaqiong Li, Hai Li, Feng Wen, David Tai Leong and Lay Poh Tan A Bio-inspired Platform to Modulate Myogenic Differentiation of Human Mesenchymal Stem Cells Through Focal Adhesion Regulation Advanced Healthcare Materials 2

Article first published online: 1 OCT 2012 | DOI: 10.1002/adhm.201200142

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This work demonstrates for the first time that it is possible to induce human mesenchymal stem cell (hMSC) differentiation by regulating the focal adhesions (FAs) without any biochemical factors. It shows that there is a synergistic effect between FAs regulation and matrix stiffness that results in a more specific and highly up-regulated myogenesis. It is also found that there is an interaction within the different physical stimulants which can only be realized if they are combined at the optimum level.

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