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Shu Chang, Xumeng Wu, Yongsheng Li, Dechao Niu, Zhi Ma, Wenru Zhao, Jinlou Gu, Wenjie Dong, Feng Ding, Weihong Zhu and Jianlin Shi A Hydrophobic Dye-Encapsulated Nano-Hybrid as an Efficient Fluorescent Probe for Living Cell Imaging Advanced Healthcare Materials 1

Version of Record online: 5 JUN 2012 | DOI: 10.1002/adhm.201200144

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Water-soluble hydrophobic-dye@nano-hybrids (DPN@NHs) with extraordinarily enhanced fluorescent performance were fabricated by encapsulating the hydrophobic dye molecules into the core of the hybrid nanospheres based on the self-assembly of amphiphilic block copolymers followed by shell cross-linking using 3-mercaptopropyltrimethoxy-silane. The DPN@NHs are 50 nm in size, are monodispersed in aqueous solution and have a quantum yield enhanced by 30 times.

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