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Juan Yang, Hui-Yuan Wang, Wen-Jie Yi, Yu-Hui Gong, Xiang Zhou, Ren-Xi Zhuo and Xian-Zheng Zhang PEGylated Peptide Based Reductive Polycations as Efficient Nonviral Gene Vectors Advanced Healthcare Materials 2

Article first published online: 4 OCT 2012 | DOI: 10.1002/adhm.201200154

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A series of reducible polycations (RPCs) based on PEGylated peptides, i.e., PolyHK6H, PolyHK6H-mPEG1, PolyHK6H-mPEG2, and PolyHK6H-mPEG3, with different poly(ethylene glycol) (PEG) contents, are synthesized. It is found that RPCs with an appropriate PEG amount have high capacity to bind and condense plasmid DNA (pDNA). PolyHK6H-mPEG1 exhibits comparable transfection efficiency in serum-free medium and higher transfection efficiency in serum-supplemented medium compared with 25 kDa polyethyleneimine (PEI).

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