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Cécile M. Bidan, Krishna P. Kommareddy, Monika Rumpler, Philip Kollmannsberger, Peter Fratzl and John W. C. Dunlop Geometry as a Factor for Tissue Growth: Towards Shape Optimization of Tissue Engineering Scaffolds Advanced Healthcare Materials 2

Article first published online: 19 NOV 2012 | DOI: 10.1002/adhm.201200159

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Bone tissue growth depends on the local curvature of the substrate. A simple mathematical model predicts the observations of in vitro tissue growth inside convex and non-convex pores. Experiments show that tissue growth rates can be doubled by changing the geometry of a prismatic pore from square to cross-like. Methods based on these observations are proposed to optimize the design of porous scaffolds.

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