Jie Tan, Wei-Jie Zhao, Jie-Kai Yu, Sai Ma, Michael J. Sailor and Jian-Min Wu Capture, Enrichment, and Mass Spectrometric Detection of Low-Molecular-Weight Biomarkers with Nanoporous Silicon Microparticles Advanced Healthcare Materials 1
Porous silicon microparticles with well controlled pore size and tailored surface chemistry can selectively capture low-molecular-weight peptides (LMWPs) within a target range of molecular size and electric charge. High-fidelity mass profiles of LMWPs can be obtained after serum samples are enriched by the microparticles, enabling cancer patients to be potentially distinguished from healthy individuals based on clustering analysis.
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