Daniel Rönnlund, Yang Yang, Hans Blom, Gert Auer and Jerker Widengren Fluorescence Nanoscopy of Platelets Resolves Platelet-State Specific Storage, Release and Uptake of Proteins, Opening up Future Diagnostic Applications Advanced Healthcare Materials 1
By super-resolution stimulated emission (STED) microscopy the spatial distribution patterns of three different regulating proteins is investigated in over 300 individual platelets, demonstrating distinct resolving advantages. Upon platelet activation, spatial rearrangements of the proteins are observed, specific for a certain protein and activation. Analysis of the protein distribution patterns can reveal the type of activation, with possible diagnostic applications.
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