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Yurina Sekine, Yuki Moritani, Tomoko Ikeda-Fukazawa, Yoshihiro Sasaki and Kazunari Akiyoshi A Hybrid Hydrogel Biomaterial by Nanogel Engineering: Bottom-Up Design with Nanogel and Liposome Building Blocks to Develop a Multidrug Delivery System Advanced Healthcare Materials 1

Version of Record online: 29 AUG 2012 | DOI: 10.1002/adhm.201200175

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Biodegradable hybrid hydrogels are obtained using nanogel-coated liposomes, which are prepared by Michael addition of the acryloyl groups of a nanogel to the thiol group, and which are terminally branched with polyethlylene glycol (PEG). The hydrogel is gradually hydrolyzed under physiological conditions releasing the nanogel and nanogel-coated liposomes. The developed hybrid hydrogel is a highly functional carrier with a time-programmed dual-release system.

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