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Sara M. Oliveira, Tiago H. Silva, Rui L. Reis and João F. Mano Hierarchical Fibrillar Scaffolds Obtained by Non-conventional Layer-By-Layer Electrostatic Self-Assembly Advanced Healthcare Materials 2

Version of Record online: 8 OCT 2012 | DOI: 10.1002/adhm.201200204

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A new application of layer-by-layer assembly is presented, able to create nano/micro fibrils or nanocoatings inside 3D scaffolds using non-fibrillar polyelectrolytes for tissue-engineering applications. This approach shows promise for developing advanced scaffolds with controlled nano/micro environments, and nature and architectures similar to the natural extracellular matrix, leading to improved biological performance.

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