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Richard A. Thibault, Antonios G. Mikos and F. Kurtis Kasper Scaffold/Extracellular Matrix Hybrid Constructs for Bone-Tissue Engineering Advanced Healthcare Materials 2

Article first published online: 28 SEP 2012 | DOI: 10.1002/adhm.201200209

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Three major types of scaffold/extracellular matrix hybrid constructs have been reported and investigated within the literature: polymeric constructs incorporating collagen and calcium phosphate, biological tissue extracellular matrix (ECM)-based constructs, and cell-generated ECM-based constructs, illustrated here. This Progress Report discusses the synthesis, characterization, and in vitro and in vivo osteogenic analysis of each type of hybrid construct.

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