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Yunlu Dai, Xiaojiao Kang, Dongmei Yang, Xuejiao Li, Xiao Zhang, Chunxia Li, Zhiyao Hou, Ziyong Cheng, Ping'an Ma and Jun Lin Platinum (IV) Pro-Drug Conjugated NaYF4:Yb3+/Er3+ Nanoparticles for Targeted Drug Delivery and Up-Conversion Cell Imaging Advanced Healthcare Materials 2

Article first published online: 2 NOV 2012 | DOI: 10.1002/adhm.201200234

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A folic acid targeted anticancer drug delivery system based on Pt (IV) complexes pro-drug conjugated up- conversion NaYF4:Yb3+/Er3+ nanoparticles has been developed. The platinum (IV) complexes as pro-drugs can exhibit anti-cancer activities when the platinum (IV) complexes are reduced to platinum (II) in the intracellular environment. Meanwhile, the drug delivery system can be used as a luminescent probe for up-conversion cell imaging.

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