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Joana Silva-Correia, Barbara Zavan, Vincenzo Vindigni, Tiago H. Silva, Joaquim M. Oliveira, Giovanni Abatangelo and Rui L. Reis Biocompatibility Evaluation of Ionic- and Photo-Crosslinked Methacrylated Gellan Gum Hydrogels: In Vitro and In Vivo Study Advanced Healthcare Materials 2

Version of Record online: 2 NOV 2012 | DOI: 10.1002/adhm.201200256

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Ionic- and photo-crosslinked methacrylated gellan gum hydrogels present promising physicochemical and biological properties for tissue engineering of nucleus pulposus. In vitro studies demonstrate the stability and encapsulation efficiency of the hydrogels with L929 cell line and primary human intervertebral disc cells. The biomaterials are able to sustain cell viability up to 21 days of culturing. The hydrogels are well-tolerated and non-toxic in vivo as shown by rat implantation.

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