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Stephany Y. Tzeng and Jordan J. Green Subtle Changes to Polymer Structure and Degradation Mechanism Enable Highly Effective Nanoparticles for siRNA and DNA Delivery to Human Brain Cancer Advanced Healthcare Materials 2

Version of Record online: 26 SEP 2012 | DOI: 10.1002/adhm.201200257

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Over 200 nanoparticle formulations based on poly(beta-amino esters) are utilized to evaluate the effect of polymer structure and nucleic acid structure on gene delivery. Highly effective polymeric nanoparticles are created to deliver siRNA and DNA to human brain cancer cells. Polymer properties, including polymer structure and degradation mechanism, are key for successful delivery.

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