E-mail a Wiley Online Library Link

Stephany Y. Tzeng and Jordan J. Green Subtle Changes to Polymer Structure and Degradation Mechanism Enable Highly Effective Nanoparticles for siRNA and DNA Delivery to Human Brain Cancer Advanced Healthcare Materials 2

Version of Record online: 26 SEP 2012 | DOI: 10.1002/adhm.201200257

Thumbnail image of graphical abstract

Over 200 nanoparticle formulations based on poly(beta-amino esters) are utilized to evaluate the effect of polymer structure and nucleic acid structure on gene delivery. Highly effective polymeric nanoparticles are created to deliver siRNA and DNA to human brain cancer cells. Polymer properties, including polymer structure and degradation mechanism, are key for successful delivery.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field