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Igor Makarovsky, Jonathan Lellouche, Jean-Paul Lellouche and Ehud Banin Improved Triclosan Delivery by a Novel Silica-Based Nanocomposite Advanced Healthcare Materials 2

Article first published online: 30 OCT 2012 | DOI: 10.1002/adhm.201200275

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The design, synthesis, and full characterization of covalently-linked, triclosan NPs, coated with a polyaminated shell (NH2-T-SNPs) are reported herein. The biological mechanism of action of these novel NPs is elucidated via various techniques. NH2-T-SNPs are found to be potently bactericidal with no detectable activation time against E. coli and S. aureus and no human cytotoxicity.

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