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Ken-ichiro Kamei, Yoshikazu Hirai, Momoko Yoshioka, Yoshihide Makino, Qinghua Yuan, Minako Nakajima, Yong Chen and Osamu Tabata Phenotypic and Transcriptional Modulation of Human Pluripotent Stem Cells Induced by Nano/Microfabrication Materials Advanced Healthcare Materials 2

Article first published online: 28 SEP 2012 | DOI: 10.1002/adhm.201200283

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Microfabrication materials such as polydimethylsiloxane (PDMS) and photoresists (PRs) permit the creation of nano/microstructured substrates that enable the direct control of the cellular functions and phenotypes of human pluripotent stem cells (hPSCs). The multiple analyses of cellular phenotypes and gene expression demonstrate that microfabrication materials preferentially direct hPSCs towards differentiation.

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