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Delphine Fayol, Nathalie Luciani, Lenaic Lartigue, Florence Gazeau and Claire Wilhelm Managing Magnetic Nanoparticle Aggregation and Cellular Uptake: a Precondition for Efficient Stem-Cell Differentiation and MRI Tracking Advanced Healthcare Materials 2

Article first published online: 1 NOV 2012 | DOI: 10.1002/adhm.201200294

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The way nanoparticles interact with stem cells influences their uptake, differentiation capacity, and subsequent fate in the organism. Here, the influence of the state of magnetic nanoparticle aggregation and the amount of internalized iron on the capacity for stem-cell differentiation is examined. Magnetophoresis, a technique to quantify magnetic labeling of individual cells, is used to establish the true cellular magnetic charge, required for a realistic evaluation of any harmful effects to cells. Importantly, high cellular iron contents are found to have a deleterious effect on the differentiation pathway of cartilage formation.

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