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Yuzhou Wu, Susann Ihme, Michaela Feuring-Buske, Seah Ling Kuan, Klaus Eisele, Markus Lamla, Yanran Wang, Christian Buske and Tanja Weil A Core–Shell Albumin Copolymer Nanotransporter for High Capacity Loading and Two-Step Release of Doxorubicin with Enhanced Anti-Leukemia Activity Advanced Healthcare Materials 2

Article first published online: 7 DEC 2012 | DOI: 10.1002/adhm.201200296

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A human serum albumin derived core-shell DOX delivery system is prepared based on an innovative protein denaturing-backfolding strategy. This system possesses a considerable DOX loading capacity, a two-step controlled drug release mechanism, attractive biocompatibility and narrow size distribution inherited from the monodisperse albumin backbone, as well as fast cellular uptake and masking of HSA epitopes due to cationization and pegylation.

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