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Michiya Matsusaki, Kayo Sakaue, Koji Kadowaki and Mitsuru Akashi Three-Dimensional Human Tissue Chips Fabricated by Rapid and Automatic Inkjet Cell Printing Advanced Healthcare Materials 2

Article first published online: 2 NOV 2012 | DOI: 10.1002/adhm.201200299

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Rapid and automatic development of three-dimensional (3D) human micro-tissue chips which integrate over 400 micro-arrays of simplified multilayered structures is carried out using inkjet printing technology. Comprehensive high-throughput assays of liver functions using the simplified 3D liver structures revealed highest functions of a sandwich structure of endothelial cells and hepatocytes. These 3D-human tissue chips may enable “total-human tissue models” for tailor-made drug screening.

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