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Adam H. Broderick, Anthony S. Breitbach, Reto Frei, Helen E. Blackwell and David M. Lynn Surface-Mediated Release of a Small-Molecule Modulator of Bacterial Biofilm Formation: A Non-Bactericidal Approach to Inhibiting Biofilm Formation in Pseudomonas aeruginosa Advanced Healthcare Materials 2

Article first published online: 20 JAN 2013 | DOI: 10.1002/adhm.201200334

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Bacterial biofilms pose persistent and costly challenges in many healthcare contexts. A non-bactericidal approach to preventing biofilm formation in the human pathogen P. aeruginosa is reported. The approach is based on the gradual release of a potent, non-bactericidal inhibitor of biofilm growth from thin polymer coatings, and can inhibit biofilm formation on film-coated surfaces and adjacent uncoated interfaces by up to 90%. This small-molecule inhibitor is not toxic to mammalian cells at concentrations required for strong anti-biofilm activity, suggesting that this approach is suited for further investigation in biomedical contexts.

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