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Emilie Secret, Kevin Smith, Valentina Dubljevic, Eli Moore, Peter Macardle, Bahman Delalat, Mary-Louise Rogers, Terrance G. Johns, Jean-Olivier Durand, Frédérique Cunin and Nicolas H. Voelcker Antibody-Functionalized Porous Silicon Nanoparticles for Vectorization of Hydrophobic Drugs Advanced Healthcare Materials 2

Article first published online: 30 NOV 2012 | DOI: 10.1002/adhm.201200335

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Mesoporous silicon nanoparticles that are able to specifically target and deliver hydrophobic anti-cancer drugs to cancer cells are developed. Porous silicon nanoparticles are functionalized with antibodies in a controlled way, in order to efficiently target cancer cells expressing the corresponding receptor. High targeting and killing efficiency is demonstrated in vitro on three types on cancer cells: neuroblastoma, glioblastoma and lymphoma cells.

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