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Ki Hyun Bae, Jeong Yu Lee, Soo Hyeon Lee, Tae Gwan Park and Yoon Sung Nam Optically Traceable Solid Lipid Nanoparticles Loaded with siRNA and Paclitaxel for Synergistic Chemotherapy with In situ Imaging Advanced Healthcare Materials 2

Version of Record online: 26 NOV 2012 | DOI: 10.1002/adhm.201200338

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Low-density lipoprotein–mimetic solid lipid nanoparticles loaded with paclitaxel, siRNA, and quantum dots for synergistic combination therapy with in situ fluorescence monitoring are developed. The SLNs exhibit no significant cytotoxicity, and the simultaneous delivery of paclitaxel and Bcl-2 siRNA synergistically promotes the apoptotic death of human lung carcinoma cells by activating caspase-mediated pathways.

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