Minglin Ma, Alan Chiu, Gaurav Sahay, Joshua C. Doloff, Nimit Dholakia, Raj Thakrar, Joshua Cohen, Arturo Vegas, Delai Chen, Kaitlin M. Bratlie, Tram Dang, Roger L. York, Jennifer Hollister-Lock, Gordon C. Weir and Daniel G. Anderson Core–Shell Hydrogel Microcapsules for Improved Islets Encapsulation Advanced Healthcare Materials 2
Article first published online: 3 DEC 2012 | DOI: 10.1002/adhm.201200341
Islets microencapsulation holds great promise to treat type 1 diabetes. Currently used alginate microcapsules often have islets protruding outside capsules, leading to inadequate immuno-protection. A novel design of microcapsules with core–shell structures using a two-fluid co-axial electro-jetting is reported. Improved encapsulation and diabetes correction is achieved in a single step by simply confining the islets in the core region of the capsules.
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