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Anna Galperin, Rachael A. Oldinski, Stephen J. Florczyk, James D. Bryers, Miqin Zhang and Buddy D. Ratner Integrated Bi-Layered Scaffold for Osteochondral Tissue Engineering Advanced Healthcare Materials 2

Article first published online: 6 DEC 2012 | DOI: 10.1002/adhm.201200345

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A degradable integrated bi-layered scaffold for osteochondral tissue engineering is fabricated. The ability of the scaffold to support in vitro simultaneous matrix deposition, adequate cell growth and cell differentiation of two distinct cell lineages, human mesenchymal stem cells and chondrocytes, in designated bone and cartilage layers of the scaffold, is demonstrated.

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