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Daniel J. Gilmartin, Maia M. Alexaline, Chris Thrasivoulou, Anthony R. J. Phillips, Suwan N. Jayasinghe and David L. Becker Integration of Scaffolds into Full-Thickness Skin Wounds: The Connexin Response Advanced Healthcare Materials 2

Version of Record online: 18 FEB 2013 | DOI: 10.1002/adhm.201200357

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The in vivo wound healing response to polymer scaffolds at the cell biology level remains little investigated. Here, a variety of scaffolds are applied to wounds and it is found that re-epithelialization is perturbed and the gap junction protein Connexin 43 is deleteriously up-regulated. Through bioactivation of scaffolds using Connexin 43 antisense oligodeoxynucleotides, the biocompatibility of scaffolds for clinical use can be improved.

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