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Zhenhua Li, Zhen Liu, Meili Yin, Xinjian Yang, Jinsong Ren and Xiaogang Qu Combination Delivery of Antigens and CpG by Lanthanides-Based Core-Shell Nanoparticles for Enhanced Immune Response and Dual-Mode Imaging Advanced Healthcare Materials 2

Version of Record online: 25 MAR 2013 | DOI: 10.1002/adhm.201200364

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Europium-doped GdPO4 hollow spheres/polymer core-shell nanoparticles are functionalized with ovalbumin (OVA) as a model antigen and an oligonucleotide (CpG) that stimulates the immune response. These functionalized core-shell nanoparticles are used as vaccines, where they enable efficient delivery of an antigen to target sites, tracking of the vaccines using non-invasive clinical imaging technology.

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