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Sundar P. Authimoolam, David A. Puleo and Thomas D. Dziubla Affinity Based Multilayered Polymeric Self-Assemblies for Oral Wound Applications Advanced Healthcare Materials 2

Version of Record online: 18 JAN 2013 | DOI: 10.1002/adhm.201200375

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In order to overcome the inadequacies in current oral mucosal treatment methods, a modular treatment strategy is proposed which utilizes biotin-streptavidin affinity linkages for developing multilayered polymeric self-assemblies. It is hypothesized that affinity based layer-by-layers (LBL) can be self-assembled through a series of mouth rinses over the oral wound surface, which will offer a desired regenerative treatment strategy through its stable barrier effects. Hence, evaluating the barrier stability of LBLs against harsh intraoral environment is a key requirement to validate its application in oral wounds.

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