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Xin Liu, Wing-Cheung Law, Mansik Jeon, Xianliang Wang, Maixian Liu, Chulhong Kim, Paras N. Prasad and Mark T. Swihart Cu2–xSe Nanocrystals with Localized Surface Plasmon Resonance as Sensitive Contrast Agents for In Vivo Photoacoustic Imaging: Demonstration of Sentinel Lymph Node Mapping Advanced Healthcare Materials 2

Article first published online: 8 JAN 2013 | DOI: 10.1002/adhm.201200388

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The promise of a new nanomaterial, Cu2–xSe nanocrystals, as a contrast agent for photoacoustic imaging is demonstrated. The Cu2–xSe nanocrystals exhibit strong optical absorption at near infrared wavelengths that can efficiently penetrate tissue. In vivo photoacoustic tomography using this nanomaterial as the contrast agent provides clear three-dimensional resolution of a sentinel lymph node in a rat model.

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