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Scott H. Medina, Gopinath Tiruchinapally, Maxim V. Chevliakov, Yasemin Yuksel Durmaz, Rachell N. Stender, William D. Ensminger, Donna S. Shewach and Mohamed E. H. ElSayed Targeting Hepatic Cancer Cells with PEGylated Dendrimers Displaying N-Acetylgalactosamine and SP94 Peptide Ligands Advanced Healthcare Materials 2

Article first published online: 3 APR 2013 | DOI: 10.1002/adhm.201200406

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Design of targeted PEGylated G5 dendrimers loaded with a chemotherapeutic agent: PEG is coupled to G5 and functionalized with NAcGal sugar molecules or SP94 peptide targeting ligands. NAcGal- and SP94-functionalized PEGylated G5 particles bind to their specific receptors expressed on the surface of hepatic cancer cells triggering receptor-mediated endocytosis, followed by PEG shedding and release of the loaded chemotherapeutic agent.

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