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David Yuen Wah Ng, Jörg Fahrer, Yuzhou Wu, Klaus Eisele, Seah Ling Kuan, Holger Barth and Tanja Weil Efficient Delivery of p53 and Cytochrome C by Supramolecular Assembly of a Dendritic Multi-Domain Delivery System Advanced Healthcare Materials 2

Article first published online: 8 MAY 2013 | DOI: 10.1002/adhm.201200419

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A versatile and efficient multidomain delivery system facilitating the cell uptake of the proteins p53 and Cytochrome C is obtained by supramolecular assembly. Such nanotransporters contain a streptavidin protein core functioning as a bio-adapter, second generation polyamidoamine dendrons for cell uptake as well as a therapeutic protein as cargo. The delivery and functional activity of tumor suppressor p53 or pro-apoptotic cytochrome c are studied in detail.

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