Sara Honarbakhsh, Richard H. Guenther, Julie A. Willoughby, Steven A. Lommel and Behnam Pourdeyhimi Polymeric Systems Incorporating Plant Viral Nanoparticles for Tailored Release of Therapeutics Advanced Healthcare Materials 2
Therapeutic poly(lactic acid) (PLA) nanofibrous matrices can trigger drug release through hybrid fabrication with plant viral nanoparticles (PVNs). PVNs comprise the native virus, Red clover necrotic mosaic virus, and a cancer therapeutic, doxorubicin. PVNs reversibly open and close with the appropriate environmental stimuli; the drug releases from the virus and diffuses through the polymeric matrix.
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