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Justine D. Mintern, Chiori Percival, Marloes M. J. Kamphuis, Wei Jin Chin, Frank Caruso and Angus P. R. Johnston Targeting Dendritic Cells: The Role of Specific Receptors in the Internalization of Polymer Capsules Advanced Healthcare Materials 2

Version of Record online: 20 JAN 2013 | DOI: 10.1002/adhm.201200441

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Dendritic cells (DCs) are an important target for vaccine delivery. It is shown that antibody functionalized polymer capsules can effectively target DCs; however, the internalization is highly dependent on the specific receptor targeted. This work highlights the importance of considering factors such as how the antibody/capsule is internalized, rather than just the target specificity.

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