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Can Xu, Youhui Lin, Jiasi Wang, Li Wu, Weili Wei, Jinsong Ren and Xiaogang Qu Nanoceria-Triggered Synergetic Drug Release Based on CeO2-Capped Mesoporous Silica Host–Guest Interactions and Switchable Enzymatic Activity and Cellular Effects of CeO2 Advanced Healthcare Materials 2

Version of Record online: 30 APR 2013 | DOI: 10.1002/adhm.201200464

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Herein, a nanoceria-triggered intracellular drug delivery platform using β-CD@CeO2-capped Fc-MSN is reported. CeO2 has different enzyme-mimetic activity at different pH conditions. It can be a capping agent and an antioxidant cell protector at physiological pH condition, while at low pH conditions, such as in lysosome, it triggers self-uncapping and has synergetic anticancer effect.

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