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Mingjie Cui, Dominik J. Naczynski, Margot Zevon, Craig K. Griffith, Larisa Sheihet, Izmarie Poventud-Fuentes, Suzie Chen, Charles M. Roth and Prabhas V. Moghe Multifunctional Albumin Nanoparticles As Combination Drug Carriers for Intra-Tumoral Chemotherapy Advanced Healthcare Materials 2

Version of Record online: 12 MAR 2013 | DOI: 10.1002/adhm.201200467

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Recombinant human albumin derived nanoparticles (ANPs) are engineered to overcome multiple barriers that challenge drug delivery and tumor chemotherapy. By integrating distinct technological features of nanoscale size variation, collagenase decoration, and modification with dual, complementary drugs (curcumin and riluzole), the ANPs can undergo enhanced intracellular uptake, penetrate deeper into solid tumor matrices, and exhibit significantly enhanced overall efficacy against melanoma in a tumor spheroid model.

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