Engui Zhao, Yuning Hong, Sijie Chen, Chris W. T. Leung, Carrie Y. K. Chan, Ryan T. K. Kwok, Jacky W. Y. Lam and Ben Zhong Tang Highly Fluorescent and Photostable Probe for Long-Term Bacterial Viability Assay Based on Aggregation-Induced Emission Advanced Healthcare Materials 3
Bacteria with compromised membranes open the access for TPE-2BA, a fluorophore with aggregation-induced emission characteristics, to approach their DNA. Such interaction selectively lights up dead bacteria. Possessing high brightness, excellent photostability, and appreciable biocompatibility, TPE-2BA represents a well-suited candidate for long-term tracking of bacterial viability and for bactericide screening.
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