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Karthikeyan Narayanan, Alex W. H. Lin, Yuangang Zheng, Nandanan Erathodiyil, Andrew C. A. Wan and Jackie Y. Ying Glucosamine-Conjugated Nanoparticles for the Separation of Insulin-Secreting Beta Cells Advanced Healthcare Materials 2

Version of Record online: 8 MAR 2013 | DOI: 10.1002/adhm.201200479

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A small molecule, glucosamine, is used as targeting moiety for insulin-secreting beta cell separation in artificial cell mixtures and tissue samples. The specificity of glucosamine allows it to be used in cell sorting applications. In addition, a thrombin-specific cleavable peptide was used as an intermediary to release nanoparticles from cell surfaces to facilitate cell attachment and proliferation.

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