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Chundayil Madathil Girish, Abhilash Sasidharan, G. Siddaramana Gowd, Shantikumar Nair and Manzoor Koyakutty Confocal Raman Imaging Study Showing Macrophage Mediated Biodegradation of Graphene In Vivo Advanced Healthcare Materials 2

Version of Record online: 2 APR 2013 | DOI: 10.1002/adhm.201200489

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Biodegradability of graphene is a crucial issue concerning the clinical translation of graphene based nano-bio systems. This confocal Raman imaging study reveals clear evidence of macrophage mediated degradation of tissue bound graphene under in vivo conditions over a period of 90 days in mouse models. In vitro studies conducted in macrophage cell lines also support the in vivo observations.

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