Mohammad R. Abidian, Eugene D. Daneshvar, Brent M. Egeland, Daryl R. Kipke, Paul S. Cederna and Melanie G. Urbanchek Neural Tissue Engineering: Hybrid Conducting Polymer–Hydrogel Conduits for Axonal Growth and Neural Tissue Engineering (Adv. Healthcare Mater. 6/2012) Advanced Healthcare Materials 1
Conduit hydrogels have been considered for axonal regeneration in both central and peripheral nervous systems. However, a drawback of hydrogel conduits is their lack of mechanical integrity and strength under physiological conditions. On page 762, M. R. Abidian and co-workers report a novel method for preparation of mechanically reinforced agarose nerve conduits that are then made conductive by use of a thin layer of conducting polymer pol(3,4-ethylenedioxythiophene) (PEDOT). The front cover illustrates axon guidance and growth inside a partially coated PEDOT agarose hydrogel conduit.
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