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Xiaochuan Ma, Xiaobo Wang, Ming Zhou and Hao Fei A Mitochondria-Targeting Gold–Peptide Nanoassembly for Enhanced Cancer-Cell Killing Advanced Healthcare Materials 2

Article first published online: 8 MAY 2013 | DOI: 10.1002/adhm.201300037

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A multifunctional nanoarchitecture with ordered molecular structures is designed and constructed as a platform for multiplexed surface biofunctionalization. The nanoassembly enters cells via caveolae-dependent endocytosis and specifically targets mitochondria. Upon cytotoxic peptide modification, the nanoassembly exhibits dramatically enhanced anticancer activities.

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