Chun-Yang Sun, Shuang Dou, Jin-Zhi Du, Xian-Zhu Yang, Ya-Ping Li and Jun Wang Doxorubicin Conjugate of Poly(Ethylene Glycol)-Block-Polyphosphoester for Cancer Therapy Advanced Healthcare Materials
A pH-sensitive polymer–doxorubicin conjugated delivery system has been designed and synthesized based on biodegradable polyphosphoesters. Such system more significantly inhibit tumor growth compared with free drug due to the prolonged circulation in blood, enhanced accumulation in tumor tissues, and selectivedrug release in tumoral cells. This research supplies an alternative choice for polymer–drug conjugated system.
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