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Jiefu Jin, Zhenhua Xu, Yue Zhang, Yan-Juan Gu, Michael Hon-Wah Lam and Wing-Tak Wong Upconversion Nanoparticles Conjugated with Gd3+-DOTA and RGD for Targeted Dual-Modality Imaging of Brain Tumor Xenografts Advanced Healthcare Materials 2

Article first published online: 30 APR 2013 | DOI: 10.1002/adhm.201300102

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A peptide-labeled paramagnetic/upconversion nanoprobe (UCNP-Gd-RGD) is designed and synthesized. It demonstrates high specificity towards U87MG cells and preferential retention in subcutaneous U87MG tumors. The tumor boundary delineation is successfully achieved through in vivo upconversion fluorescence and MRI studies. This dual-modal nanoprobe holds the potentials in preoperative MR imaging and intra-operative fluorescence-guided surgery

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