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Peter C. DeMuth, Younjin Min, Darrell J. Irvine and Paula T. Hammond Implantable Silk Composite Microneedles for Programmable Vaccine Release Kinetics and Enhanced Immunogenicity in Transcutaneous Immunization Advanced Healthcare Materials 3

Article first published online: 12 JUL 2013 | DOI: 10.1002/adhm.201300139

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Composite dissolving microneedles composed of vaccine-loaded (ovalbumin–red and blue), controlled-release silk hydrogel tips supported on rapidly soluble PAA pedestals provide non-invasive transcutaneous implantation of persistent microscopic silk implants for sustained vaccine release together with bolus delivery of PAA-loaded cargos in vivo. Programmable long-term vaccine release together with microneedle administration enhanced cellular and humoral immune responses relative to parenteral immunization.

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