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Takashi Hoshiba, Mayo Nikaido and Masaru Tanaka Characterization of the Attachment Mechanisms of Tissue-Derived Cell Lines to Blood-Compatible Polymers Advanced Healthcare Materials 3

Version of Record online: 16 SEP 2013 | DOI: 10.1002/adhm.201300309

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Cancer cells can attach to blood compatible poly(2-methoxyethyl acrylate) (PMEA) and poly(tetrafurfuryl acrylate) (PTHFA) substrates. After cell attachment sites in adsorbed fibronectin, but not fibrinogen, are exposed by adsorption, cancer cells but not platelets attach to PTHFA substrates via only integrin-dependent mechanism. In contrast, the cells attach to PMEA substrate via integrin-dependent and -independent mechanisms.

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