Lei Song, Vincent H.B. Ho, Chun Chen, Zhongqiang Yang, Dongsheng Liu, Rongjun Chen and Dejian Zhou Drug Delivery: Efficient, pH-Triggered Drug Delivery Using a pH-Responsive DNA-Conjugated Gold Nanoparticle (Adv. Healthcare Mater. 2/2013) Advanced Healthcare Materials 2
A novel pH-responsive DNA–gold nanoparticle conjugate that has high drug load, resists non-specific serum protein adsorption and has high endocytotic cellular uptake is developed by Dejian Zhou, Rongjun Chen, and co-workers on page 275. Upon acidification in intracellular endosomes/lysosomes, the formation of intramolecular i-motif by the pH-responsive DNA leads to efficient, pH-triggered release of the anticancer drugs inside cancer cells, and hence high cytotoxicity.
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