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Delphine Fayol, Nathalie Luciani, Lenaic Lartigue, Florence Gazeau and Claire Wilhelm Managing Magnetic Nanoparticle Aggregation and Cellular Uptake: a Precondition for Efficient Stem-Cell Differentiation and MRI Tracking (Adv. Healthcare Mater. 2/2013) Advanced Healthcare Materials 2

Article first published online: 11 FEB 2013 | DOI: 10.1002/adhm.201370011

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The influence of the state of magnetic nanoparticle aggregation and the amount of internalized iron on capacity for stem-cell differentiation is examined by Claire Wilhelm and co-workers on page 313. The image shows stem cells covered by rod-shaped aggregates of magnetic nanoparticles, and observed by optical microscopy (background), electron microscopy (top left quadrant), and magnetophoresis (bottom). High cellular iron contents are found to have a deleterious effect on the differentiation pathway of cartilage formation. STEM

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