Ki Hyun Bae, Jeong Yu Lee, Soo Hyeon Lee, Tae Gwan Park and Yoon Sung Nam Cancer Therapy: Optically Traceable Solid Lipid Nanoparticles Loaded with siRNA and Paclitaxel for Synergistic Chemotherapy with In situ Imaging (Adv. Healthcare Mater. 4/2013) Advanced Healthcare Materials 2
Optically traceable, low-density lipoprotein (LDL)-mimetic solid lipid nanoparticles (SLNs) loaded with Bcl-2 siRNA, paclitaxel, and CdSe/ZnS quantum dots for synergistic combination chemotherapy are reported by Yoon Sung Nam and co-workers on page 576. The LDL-mimetic SLNs deliver both paclitaxel and siRNA and exhibit synergistic anticancer activities through caspase-mediated apoptosis. The strong fluorescence from the quantum dots enables in situ optical monitoring of drug delivery.
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